Here is an article from the New York Times on Suffering.
It poses some interesting questions and makes some cogent observations. He is correct when he says that you crash through the floor of your personality, into deeper and deeper zones of the unknown. What we do with this varies according to the individual. There is potential for rediscovery here, but it takes an agonizing amount of work and persistence. There are degrees of suffering and the causes are myriad. There are some commonalities and many differences. All in all, a worthwhile read.